Antimicrobial PK/PD
Every antimicrobial pk/pd calculator on CalcEngines — unit converters, derived indices and interpretive tools, each with its formula, a worked example and the reference intervals it is judged against.
8 calculators in this section
- AUC24/MIC Ratio CalculatorDivide a 24-hour area under the concentration-time curve by the MIC — the exposure target for vancomycin and the fluoroquinolones — and see what the ratio becomes one doubling dilution either side of the reported MIC.
- Cmax/MIC Ratio CalculatorThe peak-to-MIC ratio — the classical aminoglycoside target, from human studies in the 1980s and 1990s — with the published graded response, the modern argument that fAUC/MIC has replaced it, and the one-dilution bracket.
- Continuous Infusion Css/MIC Ratio CalculatorUnder a continuous infusion fT>MIC is 100% by construction, so the target stops being a time fraction and becomes a concentration multiple. This gives the free steady-state concentration as a multiple of the MIC, against the 4-to-8 window.
- Extended vs Intermittent Infusion CalculatorThe same dose at the same interval, over 30 minutes and over several hours: how many percentage points of fT>MIC the longer infusion buys, from the exact one-compartment steady-state equations.
- Free Drug Concentration CalculatorConvert a total concentration to unbound drug, or back, from the protein binding percentage — because only free drug is active, and for a 95%-bound agent the two differ twentyfold.
- MIC Doubling Dilution Uncertainty CalculatorMICs are powers of two because the test is a doubling dilution series, so a reported MIC is a bracket rather than a value. This turns that bracket into the range of PK/PD ratios it actually permits.
- PK/PD Target Interpreter: Which Index for Which DrugMatching an antibiotic class to the wrong pharmacodynamic index is the error this category exists to prevent. Choose the class and the endpoint and this names the index, the published target, the model and organism it came from, and whether it is free or total drug.
- Time Above MIC Calculator (fT>MIC)The fraction of the dosing interval during which free drug stays above the MIC — the target that belongs to the beta-lactams, computed in closed form from the peak, the half-life and the interval, with what one doubling dilution of MIC does to it.