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Tobramycin Unit Converter
Tobramycin is an aminoglycoside antibiotic used to treat serious bacterial infections caused by gram-negative organisms, including Pseudomonas aeruginosa. It has a narrow therapeutic index, meaning the difference between effective and toxic doses is small.
Therapeutic Drug Monitoring (TDM) is critical to ensure efficacy while minimizing the risk of nephrotoxicity (kidney damage) and ototoxicity (hearing loss). This converter facilitates switching between standard mass units (μg/mL, mg/L) and SI molar units (μmol/L).
Mass Units
StandardMicrograms per milliliter (Numerically equivalent to mg/L).
SI / Molar Units
Micromoles per liter (International Standard).
Clinical Context
Standard Dosing Targets:
• Peak: 5 – 10 μg/mL (usually 30 mins after infusion).
• Trough: < 2.0 μg/mL (to avoid toxicity).
Extended-Interval Dosing: Uses a nomogram (e.g., Hartford) where random levels are checked 6–14 hours post-dose. Trough levels are typically undetectable.
Conversion Logic:
Molecular Weight of Tobramycin: 467.52 g/mol.
1 μg/mL ≈ 2.14 μmol/L.
1 μmol/L ≈ 0.468 μg/mL.
Clinical References
How to Use This Converter
Follow these steps to normalize Tobramycin values.
Enter Values
Input your laboratory result into the corresponding unit field (e.g., μg/mL).
Automatic Conversion
The calculator converts between mass units and the SI molar unit using the molecular weight of 467.52 g/mol.
Reset
Use the Clear button to reset all fields.
Frequently Asked Questions
Yes. 1 microgram per milliliter is numerically identical to 1 milligram per liter.
High trough levels indicate drug accumulation and significantly increase the risk of kidney damage and hearing loss.