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Asparagine (Asn) Unit Converter
Asparagine (Asn) is a non-essential alpha-amino acid that plays a critical role in the biosynthesis of glycoproteins and other proteins. It is synthesized in the body from aspartate and glutamine by the enzyme asparagine synthetase. Physiologically, it serves as a reservoir for ammonia storage and transport, participating in the urea cycle and nitrogen metabolism.[Image of urea cycle]
Clinically, measuring asparagine levels is vital in the management of Acute Lymphoblastic Leukemia (ALL). Leukemic cells, unlike normal cells, often lack asparagine synthetase and depend on circulating asparagine for survival. Treatment with the enzyme L-Asparaginase depletes serum asparagine, starving the cancer cells. Monitoring serum levels helps ensure therapeutic depletion (< 2 µmol/L) is achieved. Additionally, low levels in cerebrospinal fluid may indicate Asparagine Synthetase Deficiency, a rare neurodegenerative disorder.
SI Units
RecommendedMicromoles per liter (Standard International).
Conventional Units
Clinical Context
Reference Ranges: In healthy adults, plasma asparagine levels typically range from 30 – 80 µmol/L (0.4 – 1.1 mg/dL). Levels in children are generally lower.
During Asparaginase therapy, the therapeutic goal is often to maintain plasma asparagine below the limit of detection or < 3 µmol/L to ensure leukemic cell starvation. Conversely, in Asparagine Synthetase Deficiency, plasma levels may be normal or low-normal, but CSF levels are diagnostically low. The conversion factor is based on MW 132.12 g/mol: 1 mg/dL ≈ 75.7 µmol/L.
Clinical References
How to Use This Calculator
Follow these steps to get accurate clinical conversions instantly.
Enter Values
Input your laboratory results into the corresponding unit field (e.g., µmol/L). You can use either dot or comma decimals.
Automatic Conversion
The calculator works in real-time. As you type in one field, all other units (like mg/dL) are instantly updated.
Verify Units
Check the SI Units section. µmol/L is the standard for amino acid quantitation.
Reset
Use the Clear button to reset all fields before starting a new calculation.
Frequently Asked Questions & Tips
1 mg/dL = 75.7 µmol/L. This is based on the molecular weight of Asparagine (132.12 g/mol).
Yes, amino acid levels fluctuate with diet. Overnight fasting is usually required for accurate baseline measurement.