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Digoxin Unit Converter
Digoxin is a widely used cardiac glycoside medication derived from the foxglove plant, utilized primarily to increase the force of myocardial contraction (positive inotropy) in heart failure and to slow the ventricular rate in atrial fibrillation. It achieves its therapeutic effect by reversibly inhibiting the myocardial Pase pump, leading to increased intracellular calcium.
Digoxin has a **narrow therapeutic index**, meaning the effective dose is very close to the toxic dose, making Therapeutic Drug Monitoring (TDM) essential. Toxicity symptoms often include cardiac arrhythmias, gastrointestinal distress, and visual disturbances (e.g., blurred or yellow vision). The drug is primarily cleared by the kidneys, necessitating careful dosing in patients with renal impairment. This converter facilitates accurate switching between the SI unit and the conventional mass unit.
SI Units
RecommendedNanomoles per liter (Standard International).
Conventional Units
Clinical Context
Therapeutic Range: The optimal therapeutic concentration for digoxin is typically 0.8 – 2.0 ng/mL (1.0 – 2.6 nmol/L), though levels for heart failure are often kept lower (0.5–0.9 ng/mL).
Toxicity is a major concern, especially when potassium levels are low (hypokalemia) or renal function declines. Digoxin levels should be measured at least 6 hours after the last dose to avoid falsely high results from drug distribution. The conversion factor relies on MW 780.95 g/mol: 1 ng/mL ≈ 1.28 nmol/L.
Clinical References
How to Use This Calculator
Follow these steps to get accurate clinical conversions instantly.
Enter Values
Input your laboratory results into the corresponding unit field (e.g., ng/mL). You can use either dot or comma decimals.
Automatic Conversion
The calculator works in real-time. As you type in one field, all other units (like nmol/L) are instantly updated.
Verify Units
Check the SI Units section. nmol/L is the international standard for TDM.
Reset
Use the Clear button to reset all fields before starting a new calculation.
Frequently Asked Questions & Tips
Yes. $1 \text{ ng/mL}$ is exactly equal to $1 \mu\text{g/L}$.
Trough levels should be drawn at least 6–8 hours after the last dose to allow for distribution from plasma into tissues.