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Beta-CrossLaps (β-CTX) Unit Converter
Beta-CrossLaps (β-CTX), or C-terminal telopeptide of type I collagen, is the most specific and sensitive biomarker for measuring bone resorption. Type I collagen makes up 90% of the organic matrix of bone. When osteoclasts degrade bone tissue, they release fragments of collagen, including the C-terminal telopeptide containing the cross-linked region, into the circulation.[Image of bone remodeling cycle showing osteoclasts]
Clinically, β-CTX is used to monitor antiresorptive therapy (like bisphosphonates or denosumab) in patients with osteoporosis or Paget’s disease. A significant decrease in serum β-CTX (often > 40%) indicates effective suppression of bone turnover. It is also used to assess fracture risk and monitor bone metastasis. Because β-CTX has a strong circadian rhythm (highest in the early morning) and is cleared by the kidneys, fasting morning samples are required for accuracy. This converter switches between the standard mass units (ng/mL, pg/mL) and the molar unit (pmol/L).
SI Units
RecommendedNanograms per liter or Picomoles per liter.
Conventional Units
Clinical Context
Reference ranges for β-CTX differ by age, sex, and menopausal status. In healthy premenopausal women, mean levels are approx. 0.29 ng/mL (290 pg/mL). In postmenopausal women with untreated osteoporosis, levels are often elevated above 0.60 ng/mL.
Target levels for effective osteoporosis therapy are generally < 0.30 ng/mL. It is crucial to note that food intake can suppress β-CTX levels by up to 50%, necessitating fasting samples. The conversion factor uses an approximate MW of 1300 Da: 1 ng/mL ≈ 769 pmol/L.
Clinical References
How to Use This Calculator
Follow these steps to get accurate clinical conversions instantly.
Enter Values
Input your laboratory results into the corresponding unit field (e.g., ng/mL). You can use either dot or comma decimals.
Automatic Conversion
The calculator works in real-time. As you type in one field, all other units (like pg/mL or pmol/L) are instantly updated.
Verify Units
Check the SI Units section. ng/L and pg/mL are numerically identical.
Reset
Use the Clear button to reset all fields before starting a new calculation.
Frequently Asked Questions & Tips
Yes. 1 ng/mL is equal to 1 µg/L.
Molar units are preferred in some international guidelines to standardize comparisons between different bone markers.